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TEST ITEMS

THE GENERATION DIAGNOSTIC SYSTEM

iFOB/Calprotectin

Abdominal pain, rectal bleeding, or altered defecation pattern are patient complaints frequently encountered by general practitioners (GPs). Most of these complaints have a nonorganic background, and the prevalence of organic bowel disease (OBD)—including inflammatory bowel disease (IBD) and colorectal cancer (CRC)—in primary care patients is approximately 7%. Distinguishing OBD from non-OBD needs to be timely, and the diagnostic workup aims at not missing OBD patients, who require subsequent work-up and referral to secondary care. Fecal calprotectin, a degradation product from neutrophil granulocytes from the mucosal layer of the colon, is increased when colonic inflammation is present and has been shown to have high diagnostic accuracy for discriminating OBD from non-OBD in secondary care. It is stable in feces for as long as 1 week at room temperature. On the other hand, immunochemical fecal occult blood tests (iFOBTs) detect hemoglobin and its early degradation products, which may indicate the presence of polyps or adenocarcinoma of the colon. Sensitivity is found to be higher for the iFOBTs than for the older, guaiac-based FOBTs that detect heme. Although these biomarkers seem very promising, the diagnostic value of calprotectin in primary care has not been studied, and data for iFOBTs is very limited in this setting. Eligible tests to meet this need are biomarkers such as fecal calprotectin and immunochemical fecal occult blood tests (iFOBTs). Several calprotectin and iFOBTs are currently available, including various ELISA methods and, more recently, point-of-care (POC) tests. POC tests may be advantageous in clinical settings such as primary care, if a rapid turnaround time is a necessity for improving patient care and a small number of specimens need to be evaluated at any given time.

References

  • 1.Kok L et al., Diagnostic Accuracy of Point-of-Care Fecal Calprotectin and Immunochemical Occult Blood Tests for Diagnosis of Organic Bowel Disease in Primary Care: The Cost-Effectiveness of a Decision Rule for Abdominal Complaints in Primary Care (CEDAR)

AFIAS

Compatible Device ichroma™ Ⅱ AFIAS-50
Detection Range iFOB: 25-1,000 ng/mL Calprotectin: 5-1,000 mg/kg feces
Sample Type 분변
CV <10%
LOD/LOQ iFOB LOD: 1.34 ng/mL LOQ: 25 ng/mL Calprotectin LOD: 5 mg/kg LOQ: 5 mg/kg
Reaction Time 10Min

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