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THE GENERATION DIAGNOSTIC SYSTEM
The C-Reactive Protein (CRP) is synthesized by the liver in response to interleukin-6 and well known as one of the classical acute-phase reactants and as a marker of inflammation. It has recently been suggested that a marker of inflammation, along with serum cholesterol, may be critical component in the development and progression of atherosclerosis[1,2]. A growing body of evidence has supported the idea that cardiovascular diseases including coronary heart disease, ischemic stroke, and acute myocardial infarction, develop, at least in part, because of a chronic low-level CRP of the vascular endothelium[3,4]. Apparently, high-sensitivity CRP (hsCRP) is emerging as the strongest and most independent predictive risk factor for atherosclerosis and CVD. American Heart Association (AHA) and the Centers for Disease Control and Prevention (CDC) issued a statement regarding use of C reactive protein to assess risk of cardiovascular diseases.
- 1. Koenig W, Sund M, Frohlich M, et al. C-reactive protein, a sensitive marker of inflammation, predicts future risk of coronary heart disease in initially healthy middle-aged men. Circulation 1999; 99:237-242.
- 2.Rifai N, Ridker PM. Proposed Cardiovascular Risk Assessment Algorithm Using High-Sensitivity C-Reactive Protein and Lipid Screening. Clin Chem 2001; 47:28-30.
- 3.Rifai N and Ridker PM. High-Sensitivity C-Reactive Protein: A novel and Promising Marker of Coronary Heart Disease. Clin Chem 2001; 47(3):403-411.
- 4. Biasucci LM, Liuzzo G, Grillo RL, et al. Elevated levels of C-reactive protein at discharge in patients with unstable angina predict recurrent instability. Circulation 1999;99:855-860.